This research explores innovative strategies for an HIV cure by focusing on the elimination of the viral reservoir - the group of latently infected cells that evade conventional treatments. The project investigates the potential of specialized, expanded Natural Killer (NK) cells to identify and destroy these infected cells. By utilizing a "Shock and Kill" approach, the study aims to reactivate latent viruses and enhance the immune system's ability to clear the infection. Through a combination of in vitro experiments and humanized mouse models, this work seeks to establish a foundation for novel, immune-based therapies in the fight against HIV.